Bromhexine supports the body's own natural mechanisms for clearing mucus from the respiratory tract.
It is secretolytic: that is, it increases the production of serous mucus in the respiratory tract and makes the phlegm thinner and less sticky. This contributes to a secretomotoric effect: it helps the cilia - tiny hairs that line the respiratory tract - to transport the phlegm out of the lungs. For this reason it is often added to some antitussive (cough) syrups.
A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties. (hydrolyzing glycosaminoglycans: tending to break down/lower the viscosity of mucin-containing body secretions/components). The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein, the presence of disulfide bonds between these macromolecules and DNA.
Mucolytics: N-acetylcysteine: an aerosolized mucolytic agent often used as adjunctive therapy for pulmonary complications of cystic fibrosis (CF) in combination with vigorous chest physiotherapy. N-acetylcysteine acts to split the sulfide bonds in the macromolecules thereby decreasing viscosity, allowing for removal by normal chest physiology. The action of N-acetylcysteine is pH dependent. Mucolytic action is significant at ranges of pH 7-9.(1)
Timolol maleate is a non-selective beta-adrenergic receptor blocker. In its oral form (Blocadren), it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its ophthalmic form (brand names Timoptol in Italy; Timoptic), it is used to treat open-angle and occasionally secondary glaucoma by reducing aqueous humour production through blockade of the beta receptors on the ciliary epithelium. The pharmacological mechanism by which it actually does this is still unknown.
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