Thiazolidinediones or TZDs act by binding
to PPARs (peroxisome proliferator-activated receptors), a group of receptor
molecules inside the cell nucleus, specifically PPAR? (gamma). The normal
ligands for these receptors are free fatty acids (FFAs) and eicosanoids.
When activated, the receptor migrates to the DNA, activating transcription
of a number of specific genes.
Genes upregulated by PPARy can be found in the main article on peroxisome
proliferator-activated receptors.
