Bupropion (INN; previously known as amfebutamone, Wellbutrin, Zyban) is an atypical antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist. Bupropion belongs to the chemical class of aminoketones and is similar in structure to the stimulant cathinone, to the anorectic diethylpropion, and to phenethylamines in general.
Fosphenytoin is approved in the united states for the short term (five days or less) treatment of epilepsy when more widely used means of phenytoin administration are not possible or are ill-advised, such as endotracheal intubation, status epilepticus or some other type of repeated seizures; vomiting, and/or the patient is unalert or not awake or both.
Fosphenytoin was more successfully used to relieve pain refractory to opiates in a 37-year-old woman with neuroma, according to Dr. Gary J. McCleane of the Rampark Pain Center in Lurgan, Northern Ireland. She was given 1,500 phenytoin equivalent units of fosphenytoin over a 24 hour period, producing pain relief that last three to fourteen weeks after each infusion, allowing her to use less opiates.
Gabapentin (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. Presently, gabapentin is widely used to relieve pain, especially neuropathic pain. Gabapentin is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized.
FDA product labels provide Professional Information about drugs. This professional information presents product monographs approved by the US Food and Drug Administration (FDA) and compiled by drug manufacturers
Levetiracetam (INN) (pronounced) is an anticonvulsant medication used to treat epilepsy. It is S- enantiomer of etiracetam, structurally similar to the prototypical nootropic drug piracetam. Along with other anticonvulsants like gabapentin, it is also sometimes used to treat neuropathic pain. Levetiracetam is marketed under the trade name Keppra. Keppra is manufactured by UCB Pharmaceuticals Inc.
Levodopa is used as a prodrug to increase dopamine levels for the treatment of Parkinson's disease, since it is able to cross the blood-brain barrier, whereas dopamine itself cannot. Once levodopa has entered the central nervous system (CNS), it is metabolized to dopamine by aromatic L-amino acid decarboxylase. Pyridoxal phosphate (vitamin B6) is a required cofactor for this decarboxylation, and may be administered along with levodopa, usually as pyridoxine.
Loratadine is a drug used to treat allergies, and marketed for its non-sedating properties. It is marketed by Schering-Plough under several trade names such as Claritin, Claritin-D, Claritine, Clarityn, Clarityne or Fristamin depending on the market; by Lek as Lomilan; by Sandoz as Symphoral; by Ranbaxy as Roletra; by Pliva as Rinolan; ; and by Wyeth as Alavert. It is also available as a generic. In a version marketed as Claritin-D or Clarinase, loratadine is combined with pseudoephedrine, a decongestant; this makes it somewhat useful for colds as well as allergies, but adds potential side-effects of insomnia, nervousness and anxiety.
Nabumetone is a non-steroidal anti-inflammatory drug of the arylalkanoic acid family (which includes diclofenac). It is manufacturered by Meda, and is available under the brand names Relafen and Relifex.
It is used to treat pain or inflammation caused by arthritis. Nabumetone works by reducing hormones that cause pain and inflammation.
It has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAID's.
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